Combining $p$-values in Meta Analysis
I came across the term meta-analysis in the previous post, and I had another question about nominal size while reading the paper of the previous post, which reminds me Keith’s notes. By coincidence, I also find the topic about meta-analysis in the same notes. Hence, this post is mainly based on Keith’s notes, and reproduce the power curves by myself.
Controlling bias and inflation in EWAS/TWAS
The post is based on the BIOS Consortium, van Iterson, M., van Zwet, E. W., & Heijmans, B. T. (2017). Controlling bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution. Genome Biology, 18(1), 19.