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Conditional Quantile Regression Forests

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Tags: Random Forests, Quantile Regression

This note is based on the slides of the seminar, Dr. ZHU, Huichen. Conditional Quantile Random Forest.

Motivation

REactions to Acute Care and Hospitalization (REACH) study

  • patients who suffer from acute coronary syndrome (ACS, 急性冠心症) are at high risk for many adverse outcomes, including recurrent cardiac (心脏的;心脏病的;心脏病患者) events, re-hospitalizations, major mental disorders, and mortality. There is an urgent need for post-discharge (出院后) chronic (长期的,慢性的) care for ACS patients.
  • developing accurate predictive models for those adverse events are the first step in response to such need.
  • The Columbia University Medical Center has established an on-going cohort since 2013, called the REactions to Acute Care and Hospitalization (REACH)
    • Includes rich and comprehensive electronic medical records (EMRs) of 1744 ACS patients
    • Provides a unique and ideal platform to develop high-dimensional statistical predictive analysis for ACS patients.

Scientific/Clinical Objectives

  • one of the adverse event is post-traumatic stress disorder (PTSD), which leads to a much higher risk of recurrent cardiovascular (心血管的) events and mortality.
  • about 20% of the patients in REACH cohort achieved a higher score based on a PTSD checklist within one month after emergency room (ER) discharge
  • goal: to develop a statistical approach to enhance the prediction of PTSD at the time of discharge

Traditional Approaches to Predict Continuous Outcome

  1. Linear Regression
    • with a set of pre-specified key predictors
    • with variable screening and selection to include a large number of potential predictors
      • LASSO
      • SCAD
      • elastic net
  2. Machine learning approach
    • random forest
    • support vector machine
    • linear discriminant analysis
    • k-means clustering

Quantile Regression

  • Conditional quantile: $Q_\tau(Y\mid X)=\inf\{y:\Pr(Y\le y\mid X)\ge \alpha\}$
  • Quantile regression (Koenker & Bassett Jr, 1978) is an extension of traditional linear regression
  • Quantile regression allows us to study the impact of predictors on different quantiles of response distribution, and thus provides a complete picture of relationship between $Y$ and $X$.

Combine the Domain Knowledge

  • Theoretical mental health for ACS survivor indicates that PTSD due to a medical event is often driven by the fear of death and recurrence
  • The impact of the fear also depends on individuals
  • REACH study have assessed the fear level using multiple measures during emergency room (ER) visits
  • Adopting such domain knowledge into the data-driven machine learning approach is potentially another direction to improve the prediction

(??Is that fair for the previous compared methods do not combine such domain knowledge)

Existing Works

Only a few previous work involving quantile related splitting criterion or prediction in regression tree or random forest.

  • Chaudhuri and Loh (2002) and Bhat et al. (2015) proposed to partition the sample using conditional quantile loss functions at a fixed quantile level
  • Meinshausen (2006) proposed to use empirical functions for predictions, but individual tree is still based on CART

Proposed Methods

A Non-parametric Interactive Quantile Model for PTSD prediction

Assume a non-parametric interactive quantile model

where

  • $y_i$: individual post-ACS PTSD scores
  • $z_i$: key predictors (level of fear during ER visit, PTSD score at baseline)
  • $x_i$: a $p$-dimensional patient profile from EMR
  • $\tau\in (0,1)$: the quantile level

Splitting Criterion

  • For any recursive partition approach, a splitting criterion is the most crucial part.
  • Classical regression tree/forest choose the optimal split that leads to the greatest reduction in Residual Sum of Squares (RSS).
  • It partitions the sample into subsets with distinctive means.

Conditional Quantile-based Splitting Criterion I

Step 1

First determine a $K$ that $\tau_k = k/(K+1),k=1,2,\ldots,K$. Build a quantile regression model for each $\tau_k$ at node $N$ as

where $\beta_N(\tau_k, 0)$ is the quantile coefficient at quantile level $\tau_k$. (?? confused about the notation, why take 0 as the second argument, got the idea in the following context). Estimate each $\beta_N(\tau_k, 0)$ by

Step 2

Re-model the data in $N$ following the split $s$ as

where $\beta_N(\tau, s) = (\beta_1(\tau, s)^T, \beta_2(\tau, s)^T)^T$ represents the quantile coefficients following the partition $s$, and

Estimate each $\beta_N(\tau_k, s)$ by

So, it seems that $\beta_1+\beta_2$ for the left child node, while $\beta_1$ for the right child node.

Step 3

Propose the first splitting criterion, extended from the concept of RSS, in the form,

where $\hat L_N(s,\tau_k) = L_N(s, \tau_k, \hat\beta(\tau_k, s))$. The term $\omega(\tau_k)$ is a predefined weight function and reflects the relative importance across quantile levels.

Step 4

Choose the optimal split by maximizing $\Delta_N(s)$, set

Splitting Criterion II

Let

Denote that

which ranges between 1 and $K$ and identifies the rank of $y_i$ with respect to the estimated conditional quantile process (?? due to $k$?) $z_i^T\hat\beta(\tau_k, 0)$.

A contingency table can be constructed based on $\hat R_i$ for each split $s$.

Comparing the Splitting Criteria

confused about the above two figures.

Algorithm for Conditional Quantile Random Forest

Let $(y_i, x_i, z_i), i=1,\ldots, n_t$ be a training data.

Step 1: Sub-sampling the training data

randomly draw a sub-sample ($m, m\le n_t$ out of $n_t$ samples without replacement) from the training data (not a bootstrap sample!?)

Step 2: Grow a tree

based on the sub-sample, at each split

  1. randomly draw $p^*\le p$ out of $p$ predictors $x$ as the potential splitting variables ($p^*$ is pre-specified number)
  2. select the optimal splitting variable using the rank score test statistics
  3. select an optimal cut-off value of the splitting variable using the proposed criterion

Step 3: Assemble a random forest

The Applications of CQRF

Applications

  • Prediction: a new patient with covariates profile $(x^*, z^*)$
    • first estimate the individualized conditional quantile effects $\beta(\tau, x^*)$ based on the constructed CQRF
    • construct the estimated conditional quantile process ${z^*}^T\hat\beta(\tau, x^*)$
    • based on the constructed conditional quantile function, we could obtain: prediction mean, prediction median, prediction interval and predicted risk assessment
  • Feature selection: evaluate and rank the importance of the splitting variables
  • Precision medicine: assessing individualized treatment effect

Estimating Algorithm of $\beta(\tau, x^*)$

Step 1

drop the vector $x^*$ into each of the tree in the forest $\cT$, and let $N_b(x^*)$ be the terminal node in the tree $T_b$ where $x^*$ lands in

Step 2

for each observation in the training sample, define a tree-based weight

and aggregate $\omega_i(x^*, b)$ over the entire forest by

where $\omega_i(x^*)$ measures how important the $i$-th observation is in estimating $\beta(\tau, x^*)$.

Step 3

construct weighted quantile regression objective function by

and estimate $\beta(\tau_t, x^*)$ on a sequence of quantile levels $\tau_t = t/(t_n+1)$ by

Step 4

construct the coefficient function $\hat \beta_\cT(\tau, x^*)$ by a nature linear spline over $\hat\beta_{\cT,\tau_t}(x^*)$.

Theoretical Properties

Under certain conditions, for fixed $x^*$, as $n\rightarrow \infty$.

Conditional Quantile Based Prediction

Conditional quantile process of $y$ given $(x^*, z^*)$:

  • Prediction mean: $E_\cT(Y\mid x^*, z^*) = \int_0^1 {z^*}^T\hat\beta_\cT(u, x^*)du$

Note that $EX=\int xp(x)dx = \int xdF(x) = \int Q_\alpha dF(Q_\alpha) = \int Q_\alpha d\alpha$.

  • Prediction median: $\hat Q_y(0.5, x^*, z^*)$
  • The $100(1-\alpha)\%$ prediction interval

Conditional Quantile Based Risk Assessment

REACH Result

Compare prediction accuracy among the following approaches

  • Marginal Quantile RF: treating both $(z, x)$ as splitting variables
  • Linear Regression with LASSO: using linear regression, regress one-month PTSD against $(x, z)$, and use a LASSO penalty to select the predictors.
  • Random Forest: build the classical mean based random forest using both $x$ and $z$ as splitting variables. The prediction interval is constructed based on predicted mean and standard deviation
  • Quantile Regression Forest: The prediction interval is based on the empirical distribution.

Conclusion for CQRF

a robust and efficient approach for improving the screening and intervention strategies.

  • it complements the mean-based approaches and fully takes the population heterogeneity into account.
  • the use of conditional quantile regression at each split also provides a convenient way to incorporate domain knowledge to improve prediction accuracy (why bother use $\beta$, directly input $x, z$ into the forest can also combine the domain knowledge)
  • incorporate with treatment assignment allow to directly estimate individualized treatment effect for precision care (?? not say related materials)

Ongoing work and future extensions

  • explore its applications in gene-environment interactions, and develop a new splitting criterion for large-scale but highly correlated genetics data
  • the approach could be extended to a longitudinal outcome, where PTSD score might be measured at different time points. (any details?!)
  • the approach could be extended to a survival outcome (any details)

Q & A

Here are the questions and the speaker’s answers, only keywords are recorded.

  • Q: How to deal with missing data?
  • A: For missed response, directly delete. For covariates, surrogate.
  • Q: What if misspecified model in the form?
  • A: The non-parametric actually is quite flexible.
  • Q: Theories about variable selection, such as some accuracy bounds?
  • A: No.
  • Q: Compared with other machine methods?
  • A: Not enough.

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